Ejaculatory-Sparing HoLEP for Enlarged Prostate

This trial tests a new surgical technique for treating an enlarged prostate. The goal is to determine if this method, called ejaculatory-sparing HoLEP (Holmium Laser Enucleation of the Prostate), can preserve normal ejaculation after surgery. Participants will receive either the standard procedure or the new ejaculatory-sparing technique. Men who are sexually active, experience bothersome urinary symptoms, and currently have normal ejaculation might be suitable candidates for the trial. As an unphased trial, this study provides a unique opportunity to contribute to medical advancements and potentially improve surgical outcomes.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Previous studies have shown that HoLEP (Holmium Laser Enucleation of the Prostate) is a safe and effective treatment for men with an enlarged prostate. It offers long-lasting results and can treat prostates of any size. However, the standard HoLEP technique often results in retrograde ejaculation (RE), affecting sexual health.

A modified version, Ejaculatory-Sparing HoLEP (ES-HoLEP), now aims to preserve the parts involved in ejaculation, providing an option for sexually active men who wish to maintain normal ejaculation. Research indicates that this method is both feasible and safe during surgery.

Researchers are excited about the ejaculatory-sparing HoLEP technique for treating an enlarged prostate because it offers a potential improvement over standard HoLEP procedures. Unlike traditional methods, this technique aims to preserve ejaculatory function, which is a significant concern for many patients undergoing prostate surgery. This could lead to a higher quality of life post-surgery by maintaining sexual function, a common trade-off with conventional treatments. By focusing on preserving this aspect of men's health, the ejaculatory-sparing approach could redefine the standard of care for enlarged prostate treatments.

This trial will compare the ejaculatory-sparing HoLEP (Holmium Laser Enucleation of the Prostate) technique with the standard HoLEP procedure. Research has shown that the ejaculatory-sparing HoLEP can help men maintain their ability to ejaculate while treating an enlarged prostate. Early results suggest this method maintains good short-term urinary function, aiding urination without causing issues. Traditional HoLEP is already known to be safe and effective for treating benign prostatic hyperplasia (BPH), but it often causes problems with ejaculation. The ejaculatory-sparing technique aims to address this issue while preserving the benefits of the standard procedure, making it a promising choice for those concerned about sexual side effects after prostate surgery.¹²³⁵⁶