324 Participants NeededMy employer runs this trial

DHEA vs Estradiol for Menopause

AV
SM
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PC
Overseen ByPamela C Garcia-Filion, MD
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: University of Arizona
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study is being done to compare two vaginal treatments, vaginal estrogen and vaginal DHEA, that are used to treat vaginal and urinary symptoms related to menopause. These symptoms may include vaginal dryness, discomfort, painful intercourse, or urinary problems and can affect quality of life and sexual health. Women who choose to participate will be randomly assigned to use one of the two treatments for a set period of time. Participants will complete questionnaires about their symptoms and sexual health and have simple vaginal testing at the beginning and end of the study. The goal of this research is to better understand how these treatments affect vaginal health and sexual function so healthcare providers can make informed treatment decisions and improve care for postmenopausal women.

Who Is on the Research Team?

MS

Molloy Shaida

Principal Investigator

University of Arizona

Are You a Good Fit for This Trial?

This trial is for women ages 40-90 who are peri- or post-menopausal and have vaginal or urinary symptoms like dryness, discomfort, or pain during sex. Participants must be able to use vaginal treatments, speak English, and give informed consent.

Inclusion Criteria

Ability to provide informed consent
English speaker
Peri- or post-menopausal status
See 3 more

Exclusion Criteria

Known allergy to study medications
I have used hormone therapy in the past 6 months.
I have a cancer of the female reproductive system.
See 2 more

What Are the Treatments Tested in This Trial?

Interventions

  • DHEA ovals
  • Estradiol 0.01% Vag Cream

Trial Overview

The study compares two vaginal treatments—DHEA ovules versus low-dose estradiol cream—to see which works better for relieving menopause-related vaginal and urinary symptoms. Women are randomly assigned to one of the two treatments.

How Is the Trial Designed?

2

Treatment groups

Active Control

Group I: Estradiol 0.01% vaginal creamActive Control1 Intervention
Group II: DHEA suppositoryActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Arizona

Lead Sponsor

Trials
545
Recruited
161,000+