Lidocaine HCl/Epinephrine for Local Anesthesia Duration

KM
FZ
Overseen ByFengrui Zhan, BS
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: Weill Medical College of Cornell University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will compare how long local anesthesia lasts when it is injected into different layers of the skin on the forearm. The investigators hypothesize that the numbing effect will last for different amounts of time depending on whether the medication is injected just under the skin or into the skin itself.

Who Is on the Research Team?

KM

Kira Minkis, MD, PhD

Principal Investigator

Weill Medical College of Cornell University

Are You a Good Fit for This Trial?

This trial is for adults (18 or older) with normal skin feeling on their forearms and nose, who can give consent. People can't join if they're pregnant, breastfeeding, have had bad reactions to local anesthetics before, or are taking certain antidepressants.

Inclusion Criteria

Ability to provide informed consent
I am 18 years old or older.
I have normal skin feeling on my nose and forearms.

Exclusion Criteria

Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated
Pregnant or breastfeeding volunteers (assessed by self-report)
I am taking MAOI or tricyclic antidepressant medications.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive intradermal and subcutaneous injections of lidocaine to assess the duration of anesthesia

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • Lidocaine HCl/Epinephrine

Trial Overview

The study tests how long the numbing effect of lidocaine with epinephrine lasts when injected into different layers of the skin on the forearm. Each participant receives injections in both ways for comparison.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Group I: Subcutaneous administration of 1.0mL of lidocaineExperimental Treatment1 Intervention
Group II: Subcutaneous administration of 0.5mL of lidocaineExperimental Treatment1 Intervention
Group III: Intradermal administration of 1.0mL of lidocaineExperimental Treatment1 Intervention
Group IV: Intradermal administration of 0.5mL of lidocaineExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Weill Medical College of Cornell University

Lead Sponsor

Trials
1,103
Recruited
1,157,000+