Tear Film Interventions for Tear Film Characteristics

(GAMBIA Trial)

This trial examines whether a special eye device can detect changes in the tear film, the thin liquid layer on the eye's surface, when using certain eye drops or wearing contact lenses. Participants will use an eye drop called Systane Complete Preservative-Free and try two types of contact lenses to identify any differences. Individuals who typically wear soft contact lenses and have healthy eyes without active conditions may be suitable for this trial. As a Phase 4 trial, this research aims to understand how the already FDA-approved treatment benefits a broader range of patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team to get a clear answer.

Research shows that Systane Complete Preservative-Free eye drops are safe for use. Studies have found that these drops effectively ease dry eye symptoms and are generally well-tolerated. No serious side effects have been reported. They provide relief for about 8 hours, making them a good option for sensitive eyes. This information should reassure participants about the safety of using Systane Complete in this trial.¹²³⁴⁵

Researchers are excited about Systane Complete Preservative-Free and its combination with senofilcon A and somofilcon A contact lenses because they offer a new approach to managing tear film characteristics, which are crucial for eye comfort and health. Unlike traditional treatments that might focus solely on artificial tears or single-type contact lenses, this combination approach leverages a preservative-free lubricant to enhance eye moisture, followed by different types of advanced contact lenses on subsequent days. This method aims to improve both the quality and stability of the tear film, potentially offering enhanced comfort and vision clarity compared to current standard treatments.

Research has shown that Systane Complete Preservative-Free eye drops effectively manage dry eye symptoms. Studies have found that these drops significantly reduce discomfort and improve quality of life for individuals with dry eyes, particularly those frequently using digital devices. The drops create a thin layer that maintains moisture and stability on the eye surface, alleviating symptoms like dryness and irritation. In this trial, participants will receive Systane Complete with either senofilcon A or somofilcon A lenses, depending on the study arm. Overall, research supports Systane Complete as a reliable choice for managing dry eyes.¹²³⁶⁷