Zynrelef or Periarticular Injections for Postoperative Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.
Who Is on the Research Team?
Andrew Waligora, MD
Principal Investigator
Allegheny Health Network
Are You a Good Fit for This Trial?
This trial is for adults aged 18-89 who have knee osteoarthritis and are scheduled to have a robot-assisted total knee replacement on one knee.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Bupivacaine
- bupivacaine-meloxicam (extended release)
- Ketorolac
- Lidocaine
Trial Overview
The study compares two ways of managing pain after knee replacement surgery: Zynrelef (a long-lasting pain relief medication) versus standard periarticular injections using drugs like ketorolac, lidocaine, or bupivacaine. Patients' pain levels and opioid use will be tracked for 72 hours after surgery.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Periarticular injection of bupivacaine-meloxicam extended release
Periarticular injection of bupivacaine, ketorolac, and lidocaine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Lead Sponsor
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