Duloxetine for Osteoarthritis
(PACE-UP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking ability in patients with knee osteoarthritis. At study visits, participants will complete surveys, perform physical function tasks, undergo non-invasive brain imaging, and undergo sensory testing.
Who Is on the Research Team?
Benedict Alter, MD, PhD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for adults with knee osteoarthritis who have ongoing knee pain. Participants should be able to walk and take part in physical tests. People with certain medical or psychiatric conditions, or those taking medications that could interfere with the study, may not be eligible.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a double-blind, cross-over treatment with duloxetine and placebo over 16 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Duloxetine
Trial Overview
The study compares duloxetine (a medication often used for pain and depression) to a placebo to see if it helps people with knee osteoarthritis walk better and be more active. Participants are randomly assigned to either group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
In Period A, participants will receive placebo. In Period B, participants will receive duloxetine.
In Period A, participants will receive duloxetine. In Period B, participants will receive placebo.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Benedict Alter
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
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