Tirzepatide vs Semaglutide for Obesity
(JOULE3 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to determine if there are differences in the effect of 12 weeks of tirzepatide versus semaglutide on energy balance in adults with obesity and without known diabetes. The main questions it aims to answer are:
\- Does tirzepatide have a greater effect on energy expenditure or energy extraction than semaglutide?
Participants will:
* Take tirzepatide or semaglutide once weekly for 12 weeks
* Undergo identical baseline and week 12 study visits (including 24-hour whole room indirect calorimeter testing, MRI scan, body composition, 3-day meal plan and stool collection)
Who Is on the Research Team?
Zubin Punthakee, MD, MSc
Principal Investigator
McMaster University
Are You a Good Fit for This Trial?
This trial is for adults with obesity who do not have diabetes. Participants should be generally healthy aside from their weight and able to attend study visits over a 12-week period.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Semaglutide
- Tirzepatide
Trial Overview
The study compares two weekly injectable medications, tirzepatide and semaglutide, over 12 weeks to see which one affects energy use and weight loss more in people with obesity. Participants are randomly assigned to one of the two treatments.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
This group will take tirzepatide once weekly for 12 weeks. Participants will be started at 2.5 mg and increase by one dose level every 4 weeks, if tolerated (allowing up to 3 dose levels over 12 weeks), to a maximum dose of 7.5 mg. Dose levels are 2.5 mg, 5 mg, 7.5 mg.
This group will take semaglutide once weekly for 12 weeks. Participants will be started at 0.25 mg and increase by one dose level every 4 weeks, if tolerated (allowing up to 3 dose levels over 12 weeks), to a maximum dose of 1 mg. Dose levels are 0.25 mg, 0.5 mg, 1 mg.
Find a Clinic Near You
Who Is Running the Clinical Trial?
McMaster University
Lead Sponsor
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