Search > Glaucoma
My employer runs this trial

Iopidine for Intraocular Pressure in Eye Conditions

TJ
Overseen ByTravis J Peck, MD
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: Retina Consultants of Delmarva
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a prospective, randomized, controlled, open-label, single-site investigator-initiated clinical trial. A total of 120 participants will be randomized in a 1:1 ratio either to receive one drop of apraclonidine 1% ophthalmic solution (Iopidine) approximately 20-30 minutes before a clinically indicated intravitreal injection of Eylea HD or Syfovre, or to a control group that will receive no pre-injection study medication.

The intravitreal injection is part of the participant's routine clinical care. The research-specific intervention for participants assigned to the Iopidine group is administration of Iopidine. Participants assigned to the control group will receive no pre-injection study medication. Both groups will undergo post-injection IOP assessments at 5, 15, and 30 minutes post-injection and transient-vision-loss assessments.

Are You a Good Fit for This Trial?

This trial is for people who need eye injections as part of their treatment for conditions like glaucoma, age-related macular degeneration, diabetic retinopathy, or retinal vein occlusion. Participants must be eligible to receive these injections and meet the study's safety requirements.

Inclusion Criteria

I am scheduled to get an eye injection with Eylea HD or Syfovre.
I have had brief vision loss after an eye injection.
I am willing and able to have eye pressure tests and complete study assessments.
See 1 more

Exclusion Criteria

Participation in another interventional clinical trial that could interfere with safety assessments or interpretation of study outcomes
Inability to complete required IOP measurements at 1, 5, 15, and 30 minutes after injection
Inability or unwillingness to provide informed consent or comply with study procedures
See 14 more

What Are the Treatments Tested in This Trial?

Interventions

  • Apraclonidine 1% ophthalmic solution

Trial Overview

The study tests if using one drop of Iopidine (apraclonidine 1%) before an eye injection can help prevent a rise in eye pressure afterward. Half the participants get Iopidine before their usual injection; the other half do not.

How Is the Trial Designed?

2

Treatment groups

Active Control

Group I: IopidineActive Control1 Intervention
Group II: ComparatorActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Retina Consultants of Delmarva

Lead Sponsor

Unbiased Results

We believe in providing patients with all the options.

Your Data Stays Your Data

We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.