50 Participants NeededMy employer runs this trial

TRYPTYR for Dry Eye Syndrome

JS
Overseen ByJamika Singleton-Garvin
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: NYU Langone Health
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research study is to determine the effectiveness of TRYPTYR as a treatment for Dry Eye Disease. The primary efficacy variable is change from baseline in the Ocular Surface Disease Index (OSDI) at week 2. The co-primary efficacy variables are change from baseline in the National Eye Institute (NEI) scale of the cornea and NEI scale of the conjunctiva at 1 month (the third visit).

Who Is on the Research Team?

GM

Giacomina Massaro-Giordano, MD

Principal Investigator

NYU Langone Health

Are You a Good Fit for This Trial?

This trial is for people diagnosed with dry eye disease. Participants should not have other serious eye conditions or recent eye surgeries, and must meet the study's health requirements.

Inclusion Criteria

I have moderate meibomian gland dysfunction.
Schirmer test (without drops) value less than 10 mm
Positive findings on ocular surface staining (NEI ≥ 3)
See 6 more

Exclusion Criteria

Pregnancy
I am currently taking steroid medication.
I do not have any serious eye conditions except dry eye.
See 2 more

What Are the Treatments Tested in This Trial?

Interventions

  • TRYPTYR (Acoltremon ophthalmic solution 0.003%)

Trial Overview

The study is testing TRYPTYR (Acoltremon ophthalmic solution 0.003%), an eye drop, to see if it helps improve symptoms of dry eye disease over a few weeks.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Dry Eye DiseaseExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

NYU Langone Health

Lead Sponsor

Trials
1,431
Recruited
838,000+