Finasteride for Periprosthetic Joint Infection
What You Need to Know Before You Apply
What is the purpose of this trial?
High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection.
The goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following:
* Blood levels of testosterone
* Amount of bacteria on the skin.
Participants will:
* Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks
* Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin
* Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).
Who Is on the Research Team?
Corey Schiffman, MD
Principal Investigator
University of Washington
Are You a Good Fit for This Trial?
This trial is for men aged 18 to 65 who have not used Finasteride, hormone therapy, or antibiotics recently. It excludes women and anyone with certain male reproductive conditions or past bad reactions to Finasteride.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Finasteride
Trial Overview
The study tests if taking Finasteride (5 mg daily) for two weeks lowers testosterone levels and reduces skin bacteria compared to a placebo. Participants are randomly assigned to either the medication or placebo group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Washington
Lead Sponsor
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