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Guaifenesin for Chronic Bronchitis

BB
Overseen ByBrian Button, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: University of North Carolina, Chapel Hill
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

A Randomized, Dosing vs Standard of Care, Single-Center, Multiple Dose Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion

Who Is on the Research Team?

BB

Brian Button, PhD

Principal Investigator

University of North Carolina, Chapel Hill

Are You a Good Fit for This Trial?

This trial is for people who have chronic bronchitis or similar lung conditions with too much mucus production. Participants should be adults experiencing ongoing problems with thick or hard-to-clear mucus.

Inclusion Criteria

Ability to produce spontaneous sputum and non-reactive to hypertonic saline for induced sputum collection
Pulmonary Function Test with FEV1/FVC less than 0.7 but greater than 0.4 at enrollment and at least 10-year history of cigarette use
I have not used guaifenesin in the past month.
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Exclusion Criteria

History of alcohol or drug abuse within one year of study start
Smokers within the past year or positive cotinine test at baseline
Pregnant or breastfeeding participants
See 10 more

What Are the Treatments Tested in This Trial?

Interventions

  • Glyceryl Guiacolate (Guaifenesin)

Trial Overview

The study compares the effects of taking oral glyceryl guiacolate (guaifenesin), a medicine that helps thin and loosen mucus, to standard care treatments. Participants are randomly assigned to either group and take multiple doses at one center.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Standard of CareExperimental Treatment1 Intervention
Group II: Glycerol GuiacolateExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of North Carolina, Chapel Hill

Lead Sponsor

Trials
1,588
Recruited
4,364,000+

Reckitt Benckiser Healthcare (UK) Limited

Industry Sponsor

Trials
33
Recruited
5,600+

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