Hypertonic Saline + Furosemide for Heart Failure
(DESAL-HEART Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
DESAL-HEART is a multicenter, randomized, open-label, blinded-endpoint, mechanistic proof-of-concept trial conducted within the Heart Failure Efficacy and Research Trial (HEART) Platform. The study will evaluate whether adding a single infusion of 3% hypertonic saline solution (HSS) to a pre-declared intravenous furosemide dose improves decongestion in patients hospitalized with acute heart failure.
Are You a Good Fit for This Trial?
This trial is for adults hospitalized with acute heart failure who need intravenous diuretics. People with certain other serious health problems or conditions that could interfere with the study may not be able to join.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests if adding a single dose of hypertonic saline (a salty solution) to standard IV furosemide (a water pill given by vein) helps remove extra fluid better in people with sudden heart failure. Participants are randomly assigned to treatment groups.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will receive a single 150 mL intravenous infusion of 3% hypertonic saline over 30 minutes, administered concurrently with a pre-declared intravenous furosemide dose. The furosemide dose will be determined by the treating clinician before randomization. Subsequent treatment will follow standard clinical care.
Participants will receive a pre-declared intravenous furosemide dose without hypertonic saline. The furosemide dose will be determined by the treating clinician before randomization using the same dosing approach as the intervention group. Subsequent treatment will follow standard clinical care.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor
Canadian VIGOUR Centre
Collaborator
University Hospital Foundation
Collaborator
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