Petrelintide for Obesity
(ZUPREME-5 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity and established cardiovascular disease (CVD).
Are You a Good Fit for This Trial?
This trial is for adults who are overweight or obese (BMI of 27 or higher) and already have heart or blood vessel disease. Participants must have previously tried but failed to lose weight through dieting.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Petrelintide
Trial Overview
The study compares a new medication called petrelintide to a placebo, both combined with diet and exercise, to see if it helps people with obesity and heart disease lose weight safely.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hoffmann-La Roche
Lead Sponsor
Dr. Levi Garraway
Hoffmann-La Roche
Chief Medical Officer since 2019
MD from the University of Basel
Dr. Thomas Schinecker
Hoffmann-La Roche
Chief Executive Officer since 2023
PhD in Molecular Biology from New York University
Zealand Pharma
Industry Sponsor
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