ALN-CIDEB for Fatty Liver Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will test a Regeneron study drug called ALN-CIDEB to find out whether it may help treat a liver disease called metabolic dysfunction-associated steatohepatitis (MASH). MASH is more advanced stage of a broader liver disease, MASLD. MASLD is a liver condition caused by too much fat building up in the liver. This can lead to liver scarring and inflammation and can reduce the liver's ability to keep the body healthy. Cell death-inducing DFFA-like effector B (CIDEB) is a protein made by liver cells that helps the liver to store fat.
The study is looking at:
* What side effects ALN-CIDEB might cause
* How well ALN-CIDEB works to change liver fat, liver injury, and liver scarring
* How ALN-CIDEB could affect the body and the liver, which can help researchers understand why ALN-CIDEB works better for some people than others
Who Is on the Research Team?
Clinical Trial Management
Principal Investigator
Regeneron Pharmaceuticals
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with MASLD (a type of fatty liver disease) who have a certain level of liver stiffness measured by a special scan. People with other serious conditions or outside the specified liver stiffness range cannot join.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- ALN-CIDEB
Trial Overview
The study compares ALN-CIDEB, an experimental drug, to a placebo in people with advanced fatty liver disease (MASH/MASLD). Participants are randomly assigned to receive either the drug or placebo to see if ALN-CIDEB improves liver health and reduces fat and scarring.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Regeneron Pharmaceuticals
Lead Sponsor
Leonard Schleifer
Regeneron Pharmaceuticals
Chief Executive Officer since 1988
MD and PhD in Medicine
George Yancopoulos
Regeneron Pharmaceuticals
Chief Medical Officer since 1997
MD from Harvard Medical School
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