Afimkibart for Ulcerative Colitis
(AMETRINE-SC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to assess the efficacy and safety of subcutaneous induction with afimkibart in participants with moderately to severely active ulcerative colitis (UC).
Who Is on the Research Team?
Clinical Trials
Principal Investigator
Hoffmann-La Roche
Are You a Good Fit for This Trial?
This trial is for people with a confirmed diagnosis of moderately to severely active ulcerative colitis who haven't responded well or can't tolerate at least one standard UC treatment. Participants must weigh at least 40 kg, be up-to-date on colon cancer screening, and women of childbearing age must use contraception.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Afimkibart
Trial Overview
The study compares afimkibart (given as an injection under the skin) to a placebo in people with moderate to severe ulcerative colitis. The goal is to see how effective and safe afimkibart is when used as an initial treatment.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants will receive afimkibart administered as subcutaneous (SC) injection.
Participants will receive placebo adminsitered as SC injection.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hoffmann-La Roche
Lead Sponsor
Dr. Levi Garraway
Hoffmann-La Roche
Chief Medical Officer since 2019
MD from the University of Basel
Dr. Thomas Schinecker
Hoffmann-La Roche
Chief Executive Officer since 2023
PhD in Molecular Biology from New York University
Chugai Pharmaceutical
Industry Sponsor
Dr. Osamu Okuda
Chugai Pharmaceutical
Chief Executive Officer since 2020
MD from Kyoto University
Dr. Mariko Y. Momoi
Chugai Pharmaceutical
Chief Medical Officer
MD from Jichi Medical University
Pfizer
Industry Sponsor
Albert Bourla
Pfizer
Chief Executive Officer since 2019
PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki
Patrizia Cavazzoni
Pfizer
Chief Medical Officer
MD from McGill University
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.