Lattice vs Conventional Radiation Therapy for Cancer

(LATTICE-PAL Trial)

This trial aims to determine if Lattice Radiation Therapy, a specialized form of radiation therapy, can reduce pain more effectively than standard radiation therapy for individuals with large tumors. The trial focuses on patients with solid tumors at least 5 cm in size that cannot be treated with surgery or standard radiation. Participants should require radiation for pain relief and be able to complete simple pain questionnaires. As a Phase 3 trial, this study represents the final step before FDA approval, offering participants an opportunity to contribute to potentially groundbreaking treatment advancements.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.

Research has shown that Lattice Radiation Therapy (LRT) is generally safe for patients. Studies have found that LRT does not lead to severe side effects, such as grade 3 toxicity, which indicates a serious level of side effects. Notably, some patients experienced pain relief and improved movement after treatment.

Researchers are excited about Lattice Radiation Therapy (LRT) because it offers a unique approach to targeting cancerous tumors. Unlike conventional radiation therapy, which delivers a uniform dose to the entire tumor, LRT uses spatially fractionated radiation to focus higher doses on specific sub-volumes within the tumor. This technique aims to maximize damage to cancer cells while minimizing harm to surrounding healthy tissue. By concentrating the treatment more precisely, LRT could potentially enhance the effectiveness and safety of radiation therapy for cancer patients.

This trial will compare Lattice Radiation Therapy (LRT) with Conventional Radiation Therapy for cancer treatment. Research has shown that LRT can effectively treat large tumors. Studies have found that LRT helps control tumor growth and quickly reduces pain for patients with large tumors. Specifically, one study noted a 22.5% decrease in tumor size and significant pain relief, suggesting that LRT can improve movement and comfort. Additionally, LRT has provided quick relief for about 80% of patients needing palliative care. Clinical experience supports LRT as a safe and promising option for managing large tumors.¹³⁶⁷⁸