Zenagamtide for Type 2 Diabetes
(AMBITION 7 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide, (the treatment being tested) or insulin glargine (a comparator) and which treatment participants get is decided by chance.
Are You a Good Fit for This Trial?
This trial is for adults with type 2 diabetes who are already taking 1 to 3 diabetes medications and have a higher risk of heart or blood vessel problems. Participants should not have other major health issues that would prevent safe participation.What Are the Treatments Tested in This Trial?
Interventions
- Zenagamtide
Trial Overview
The study compares two injectable treatments: zenagamtide (the new drug) versus insulin glargine, both given once a week. Which treatment each participant gets is decided randomly.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will receive zenagamtide subcutaneously once weekly to one of the body parts: thigh, abdomen or upper arm.
Participants will receive Insulin glargine U-100 subcutaneously once daily to one of the body parts: thigh, abdomen or upper arm.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Novo Nordisk A/S
Lead Sponsor
Lars Fruergaard Jørgensen
Novo Nordisk A/S
Chief Executive Officer since 2017
MSc in Finance and Business Administration, Aarhus School of Business, Aarhus University, Denmark
Martin Holst Lange
Novo Nordisk A/S
Chief Medical Officer since 2021
MD from University of Copenhagen
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.