Spray Cryotherapy for Tracheal Stenosis

(Cryo-BAS Trial)

This trial tests a new treatment for benign airway stenosis (narrowing of the airway) using spray cryotherapy (a treatment that uses extreme cold) combined with balloon dilatation. Researchers aim to determine if this method reduces the need for additional treatments compared to current standard methods, such as steroid injections and balloon dilatation. The study also evaluates patient experience, safety, and any changes in the airway. Individuals with simple airway narrowing that causes symptoms and an airway diameter of less than 1 cm may be eligible to participate. As a Phase 2 trial, the research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that spray cryotherapy is generally safe for treating benign tracheal stenosis, a narrowing of the airway. Past studies have used it successfully to keep the airway open without major side effects. The treatment involves applying very cold liquid nitrogen to the inside of the airway to reduce the obstructing tissue.

Researchers are excited about spray cryotherapy for tracheal stenosis because it offers a unique way to treat airway narrowing. Unlike standard treatments like steroid injections, radial mucosal incisions, and balloon dilation, spray cryotherapy uses extreme cold to freeze and remove scar tissue in the trachea. This method can potentially lead to better airway healing and reduce the recurrence of narrowing. Additionally, spray cryotherapy is minimally invasive and can be a quick procedure, making it an appealing option for patients and doctors alike.

Research has shown that spray cryotherapy, one of the treatments studied in this trial, effectively treats tracheal stenosis, a condition where the airway becomes too narrow. Studies have found that spray cryotherapy helps keep the airway open in all patients without major side effects. A review found that it significantly improves breathing by reducing airway narrowing. In this trial, some participants will receive spray cryotherapy combined with balloon dilation. Another study suggested that adding spray cryotherapy to standard treatments might lower the chance of the narrowing returning within six months. These findings support spray cryotherapy as a promising treatment option for improving airway function.¹²³⁵⁶