Ceftazidime + Vancomycin for Surgical Site Infections
What You Need to Know Before You Apply
What is the purpose of this trial?
The research team hypothesizes that ceftazidime, in conjunction with vancomycin, is a safe and effective way to prevent surgical site infections in lumbar spinal surgery.
Objective 1: Evaluate the drain and serum concentrations of ceftazidime + vancomycin from 0-3 days postoperative. Hypothesis: The investigators hypothesize that intrawound ceftazidime will remain concentrated at the wound site, and there will be minimal absorption of ceftazidime into the circulatory system.
Objective 2: Evaluate incidence of surgical site infections (within 90 days postoperative) and pseudoarthrosis (within 2 years postoperative) after the use of ceftazidime in addition to vancomycin. Hypothesis: The investigators hypothesize that intrawound ceftazidime, in conjunction with intrawound vancomycin, is a safe and effective way to reduce surgical site infections following lumbar spine surgery, while having little effect on construct fusion (e.g., pseudoarthrosis).
Objective 3: Evaluate ceftazidime concentration effects on osteoblasts, specifically metabolic activity and osteogenic protein expression profiles. Hypothesis: The investigators hypothesize that ceftazidime concentrations measured from drain samples will not have an effect on metabolic activity and osteogenic protein expression of osteoblasts.
Who Is on the Research Team?
Brian Karamian, MD
Principal Investigator
University of Utah Orthpaedic Center
Are You a Good Fit for This Trial?
This trial is for people undergoing lumbar spine fusion surgery. It does not specify detailed inclusion or exclusion criteria, but participants are likely adults scheduled for this type of back surgery.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Ceftazidime
- Vancomycin
Trial Overview
The study tests whether applying the antibiotics ceftazidime and vancomycin directly to the surgical site can safely prevent infections after lumbar spinal fusion. Researchers will monitor drug levels and infection rates after surgery.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Topical ceftazidime and vancomycin after lumbar spinal fusion surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor
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