Ketamine + Psychotherapy for Suicidal Thoughts

(ASPIRED Trial)

This trial tests whether a one-time ketamine injection combined with a brief therapy session can quickly reduce suicidal thoughts in individuals visiting the emergency department for these reasons. Participants will receive either ketamine (an injectable solution) or a placebo, along with various types of therapy or safety planning. The study aims to identify fast and effective methods to assist those in crisis before hospital admission. It suits adults experiencing serious suicidal thoughts who can communicate in English. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.

Research has shown that ketamine is generally safe for short-term use in people with suicidal thoughts. Studies have found that just one dose of ketamine can quickly lessen these thoughts, sometimes within 24 hours. In controlled trials, participants who received ketamine reported fewer suicidal symptoms compared to those who did not.

Researchers are excited about using ketamine for suicidal thoughts because it works much faster than traditional antidepressants, which can take weeks to become effective. Ketamine, an anesthetic with unique properties, shows promise in reducing suicidal thoughts within hours or days. This rapid action is crucial for individuals in crisis. Furthermore, combining ketamine with Crisis Response Planning or safety plans offers a comprehensive approach that not only addresses immediate symptoms but also helps develop long-term coping strategies. Unlike standard treatments that typically rely on serotonin pathways, ketamine targets the brain's glutamate system, offering a novel way to potentially enhance mental health outcomes.

Research has shown that ketamine can quickly reduce suicidal thoughts. In some studies, patients who received ketamine felt significantly better and experienced fewer suicidal thoughts within hours. This positive effect can last for days or even weeks, making ketamine a viable option for urgent situations. In this trial, participants may receive ketamine combined with Crisis Response Planning (CRP) or a Safety plan control. Ketamine affects a brain chemical called glutamate, which helps control mood. Combining ketamine with therapy might yield even better results, as therapy provides strategies to manage distressing thoughts. Overall, early research suggests ketamine is a promising option for individuals with severe suicidal thoughts.