Enfortumab Vedotin for Thyroid Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests how well giving enfortumab vedotin works for the treatment of differentiated thyroid cancer that does not respond to treatment with radioiodine (refractory), anaplastic thyroid cancer, medullary thyroid cancer or NUT carcinoma that cannot be removed by surgery (unresectable) or that has spread from where it first started (primary site) to other places in the body (metastatic). Enfortumab vedotin is a monoclonal antibody, enfortumab, linked to an anticancer drug called vedotin. It works by helping the immune system to slow or stop the growth of cancer cells. Enfortumab attaches to a protein called nectin-4 on cancer cells in a targeted way and delivers vedotin to kill them. It is a type of antibody-drug conjugate.
Who Is on the Research Team?
Jochen H Lorch, MD
Principal Investigator
Northwestern University
Are You a Good Fit for This Trial?
This trial is for people with certain types of thyroid cancer (differentiated, anaplastic, medullary) or NUT carcinoma that cannot be removed by surgery or has spread to other parts of the body and does not respond to radioiodine treatment.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Enfortumab Vedotin
Trial Overview
The study is testing enfortumab vedotin, a targeted antibody-drug therapy designed to find and kill cancer cells. Participants will also have imaging scans, biopsies, and surveys as part of the research.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients receive enfortumab vedotin intravenously (IV) on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, x-ray imaging or MRI and blood and urine sample collection throughout the study and optionally undergo biopsy at progression.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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