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147 Participants NeededMy employer runs this trial

HMPL-A830 for Cancer

Recruiting at 13 trial locations
Age: 18+
Sex: Any
Trial Phase: Phase 1 & 2
Sponsor: Hutchmed
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a first-in-human (FIH), multicenter, open-label, phase I/Ⅱa clinical study of HMPL-A830 in participants with histologically or cytologically confirmed, unresectable, advanced, or metastatic solid tumors\*, who are refractory or progressed on/after available standard treatment. The study will be conducted in 2 parts:

Dose Escalation (Part A, Phase I), approximately 57 participants will be enrolled.

Dose Optimization (Part B, Phase IIa), approximately 90 participants will be enrolled.

Are You a Good Fit for This Trial?

This trial is for adults (18+) with advanced or metastatic solid tumors that can't be removed by surgery and have not responded to standard treatments. Participants must be in good physical condition, able to care for themselves, have a life expectancy of at least 12 weeks, and at least one tumor that can be measured.

Inclusion Criteria

I am fully active or restricted in physically strenuous activity only.
Participants must have at least one measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
Life expectancy ≥ 12 weeks
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Exclusion Criteria

I have not recently used strong CYP3A4, P-gp, or BCRP inhibitor medications.
I have had major surgery within the last 28 days.
Known hypersensitivity to any component of HMPL-A830
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What Are the Treatments Tested in This Trial?

Interventions

  • HMPL-A830

Trial Overview

The study is testing a new drug called HMPL-A830 in people with advanced solid tumors. It will first find the safest dose (Phase I), then test how well it works (Phase IIa). All participants receive HMPL-A830; there is no placebo group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Part B (Dose Optimization)Experimental Treatment1 Intervention
Group II: Part A (Dose Escalation)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Hutchmed

Lead Sponsor

Trials
38
Recruited
6,700+

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