Empowerment-Based Intervention for Smoking Cessation

(CHERC Trial)

This trial aims to help sexual and/or gender minority (SGM) individuals quit smoking, particularly those in areas with high stigma against SGM communities. The trial tests an empowerment-based approach called Empowering Cessation for the ACS South, which combines smoking cessation support with volunteering activities tailored for the SGM community. Participants will be divided into two groups: one receiving both smoking cessation tools and volunteering opportunities, and the other receiving only the smoking cessation tools. Ideal candidates are SGM-identifying individuals living in Oklahoma, Texas, or Arkansas, who currently smoke and are eager to quit within the next 30 days. As a Phase 2, Phase 3 trial, this study evaluates the treatment's effectiveness and represents the final step before FDA approval, offering participants a chance to contribute to groundbreaking research.

The trial does not specify if you need to stop taking your current medications, but you cannot be using other smoking cessation treatments while participating.

Studies have shown that using nicotine replacement therapy (NRT), such as patches or gum, along with habit-changing support, is generally safe and well-tolerated for quitting smoking. Participants in other research reported few serious side effects from NRT. Combining these aids with non-drug support appears to enhance success in quitting smoking without major safety concerns.

For the study's volunteering component, specific safety data is not yet available. However, similar programs that combine activities with smoking cessation have not reported major issues. The trial's advanced stage suggests that earlier studies found the treatment to be acceptably safe.

Researchers are excited about this smoking cessation intervention because it combines traditional nicotine replacement therapy (NRT) with a unique digital and community engagement approach. Unlike standard treatments that primarily focus on nicotine replacement through lozenges, gum, or patches, this intervention leverages a smoking cessation app and incorporates online volunteering activities specifically designed for sexual and gender minority communities. This innovative blend aims to enhance support networks and foster a sense of empowerment, potentially leading to more effective and sustained quitting outcomes.

Studies have shown that combining support to quit smoking with nicotine replacement products can significantly increase the chances of quitting. Specifically, participants who completed the program achieved quit rates of up to 33% in the short term and 28% in the long term. In this trial, one group will receive smoking cessation support combined with volunteering activities, which research suggests can boost motivation and confidence—key factors for quitting smoking. Another group will receive only smoking cessation support. Apps designed to assist in quitting can also enhance engagement and commitment to the process. Together, these elements aim to make the Empowering Cessation program as effective as possible.²⁴⁶⁷⁸