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158 Participants NeededMy employer runs this trial

Tulisokibart for Pulmonary Sarcoidosis

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Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Merck Sharp & Dohme LLC
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

Researchers are looking for new ways to treat active pulmonary sarcoidosis (PS).

This trial will help researchers learn if a trial medicine called tulisokibart can treat symptoms of active PS. The goal of this trial is to learn if tulisokibart works better than placebo to increase the length of time until PS gets worse.

Who Is on the Research Team?

MD

Medical Director

Principal Investigator

Merck Sharp & Dohme LLC

Are You a Good Fit for This Trial?

This trial is for adults who have had sarcoidosis affecting their lungs for at least 6 months, confirmed by a tissue biopsy and imaging tests. Their lung disease must be active within the last 3 months.

Inclusion Criteria

I have had active lung sarcoidosis in the past 3 months.
I have lung involvement from sarcoidosis shown on a chest X-ray or CT scan.
I was diagnosed with sarcoidosis at least 6 months ago by a tissue biopsy.

Exclusion Criteria

Is a current smoker defined as smoking or vaping of inhaled preparations of nicotine, tobacco, or cannabis preparations within 6 months before Screening
Has any condition that may interfere with the ability to adhere to oral corticosteroid therapy or taper
I have or had active tuberculosis.
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What Are the Treatments Tested in This Trial?

Interventions

  • Tulisokibart

Trial Overview

The study compares a new medicine called tulisokibart to a placebo (inactive treatment), both given along with standard prednisone therapy, to see if tulisokibart can delay worsening of lung sarcoidosis symptoms.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: TulisokibartExperimental Treatment2 Interventions
Group II: PlaceboPlacebo Group2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Merck Sharp & Dohme LLC

Lead Sponsor

Trials
4,096
Recruited
5,232,000+
Chirfi Guindo profile image

Chirfi Guindo

Merck Sharp & Dohme LLC

Chief Marketing Officer since 2022

Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business

Robert M. Davis profile image

Robert M. Davis

Merck Sharp & Dohme LLC

Chief Executive Officer since 2021

JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University

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