Soy Isoflavones for Wheezing
(GSV Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
In this study, we will assess whether children without established asthma who have a variation in the switch for the PAI-1 gene will have higher PAI-1 levels and remodeling / allergic inflammatory pathways in their airways than children who do not have the gene. We will also determine if soy isoflavones given when presenting for an acute respiratory illness can decrease these changes.
Who Is on the Research Team?
Rajesh Kumar, MD, MSCI
Principal Investigator
Ann & Robert H Lurie Children's Hospital of Chicago
Are You a Good Fit for This Trial?
This trial is for children who do not have a diagnosis of asthma but may be at risk. It focuses on those with or without a specific variation in the PAI-1 gene and who experience acute respiratory illnesses.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Soy Isoflavone Nutritional Supplements
Trial Overview
The study tests whether giving soy isoflavone supplements to children during an acute respiratory illness can reduce airway inflammation, especially in those with a certain PAI-1 gene variation. The effects are compared between groups.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
soy isoflavone at 1.5 mg/kg divided bid dosed from presentation for 2 - 3 day sof dosing
these subjects will have endotyping carried out by nasal swab at presentation and day 7
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ann & Robert H Lurie Children's Hospital of Chicago
Lead Sponsor
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