FTT-PET and ctDNA for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This multicenter center, open-label, baseline-controlled diagnostic imaging study designed to assess the use of Fluorthanatrace-Positron Emission tomography (FTT-PET) as a PARP inhibitor (PARPi) therapy predictive imaging biomarker and the use of EnhanceAR-Seq (ctDNA) in predicting response to therapy and to identify genomic alterations associated with resistance. Furthermore, to correlate changes in ctDNA and imaging (FTT-PET and standard of care imaging) to understand the dynamics of tumor response.
Who Is on the Research Team?
Farrokh Dehdashti, MD
Principal Investigator
Washington University School of Medicine
Are You a Good Fit for This Trial?
This trial is for people with metastatic prostate cancer. Participants should be adults who are able to undergo PET/CT scans and blood tests, and are candidates for PARP inhibitor therapy.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study is testing whether a special PET scan (FTT-PET) and a blood test that looks at tumor DNA (ctDNA via EnhanceAR-Seq) can predict how well patients will respond to PARP inhibitor treatment.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will undergo two FluorThanatrace (FTT) Positron Emission Tomography/Computed tomography (PET/CT) scans; one at baseline prior to starting standard of care (SOC) PARP inhibitor (PARPi) therapy and one two weeks after initiation of PARPi therapy. Each cycle of PARPi therapy is 28 days. Blood samples for EnhanceAR-Seq ctDNA analysis will be collected from participants at baseline prior to therapy, post cycle 1,12 weeks after PARPi initiation, and at time of disease progression. Eight participants will undergo an additional FTT-PET/CT prior to initiation of PARPi therapy.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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