90 Participants NeededMy employer runs this trial

Androgen Deprivation Therapy + Radiotherapy for Prostate Cancer

NY
Overseen ByNina Yang, RN
Age: 18+
Sex: Male
Trial Phase: Phase 2
Sponsor: NYU Langone Health
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

For this study, high risk prostate cancer patients with lower risk ARTERA scores will be treated with 6 months of Androgen Deprivation Therapy (ADT) in conjunction with dose escalated radiotherapy to the prostate and nodes. Specifically, patients enrolled in this study will undergo one of several dose-escalated forms of radiotherapy which would include SBRT with or without a brachytherapy boost.

Who Is on the Research Team?

MZ

Michael Zelefsky, MD

Principal Investigator

NYU Langone Health

Are You a Good Fit for This Trial?

This trial is for men with high-risk prostate cancer who have lower risk ARTERA scores. Participants should be healthy enough for hormone therapy and radiation, and not have conditions that would prevent them from completing treatment.

Inclusion Criteria

MRI findings: Lesion may have extracapsular extension (ECE)
No imaging evidence of nodal metastases on baseline MRI/CT of the pelvis and PET-PSMA scans
Serum testosterone ≥ 120 ng/dL prior to ADT start
See 9 more

Exclusion Criteria

IPSS > 22
Contraindications to receiving gadolinium contrast
I have had hormone therapy for prostate cancer for 3 months or less.
See 13 more

What Are the Treatments Tested in This Trial?

Interventions

  • Androgen Deprivation Therapy (ADT)
  • Radiotherapy

Trial Overview

The study tests if a short course (6 months) of hormone therapy (ADT) combined with higher-dose radiotherapy—including SBRT, possibly with brachytherapy—works well in these patients.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: High-Risk Prostate Cancer Patients with Lower-Risk ARTERA ScoresExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

NYU Langone Health

Lead Sponsor

Trials
1,431
Recruited
838,000+