Ivermectin for Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The researchers are doing this study to find out whether the combination of ivermectin and standard of care prophylaxis (SOCP; drugs given to prevent the development of a disease or condition) is an effective treatment approach for people with skin side effects caused by daraxonrasib treatment (daraxonrasib-induced skin toxicity). The researchers will compare the combination of ivermectin and SOCP with SOCP alone to see which treatment approach is more effective. The researchers will also look at how the study treatments impact participants' quality of life. The researchers will measure quality of life by having participants complete questionnaires.
Who Is on the Research Team?
Allison Gordon, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for people with pancreatic cancer who are experiencing skin side effects from the drug daraxonrasib. Participants must be able to use creams and medications on their skin as part of the study.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Ivermectin
Trial Overview
The study compares standard treatments for skin problems (like steroid creams, antibiotics, and photoprotection) with or without adding ivermectin to see which works better at preventing or treating daraxonrasib-related skin issues.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Ivermectin 200mcg/kg orally weekly PLUS SOCP above as in Arm A
Minocycline Face: Hypochlorous acid solution Face: Hydrocortisone Trunk: Triamcinolone Scalp: Clobetasol propionate Photoprotection: Broad-spectrum sunscreen
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
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