Low Dose Radiation Therapy for Knee Osteoarthritis

MW
Overseen ByMarissa Weiss
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Wisconsin, Madison
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to learn if one course of low-dose radiation therapy (LDRT) helps as much as two courses of LDRT in people with osteoarthritis.

The main questions it aims to answer are whether pain control, joint function, and quality of life are the same with one course of LDRT.

Participants will receive LDRT and can expect to be in the study for up to 3 months.

Who Is on the Research Team?

JS

Jessica Schuster, MD

Principal Investigator

University of Wisconsin, Madison

Are You a Good Fit for This Trial?

This trial is for adults with knee osteoarthritis who are seeking relief from joint pain and stiffness. People with other major health issues or conditions that could interfere with the study may not be able to participate.

Inclusion Criteria

I have been diagnosed with knee osteoarthritis.
I am at least 40 years old.
I have had joint pain for at least 3 months.
See 2 more

Exclusion Criteria

I have been diagnosed with rheumatoid arthritis, pseudogout, or gout in my joint.
I have had or will have surgery on my affected joint within 6 months.
I have had radiation therapy to the affected joint.
See 1 more

What Are the Treatments Tested in This Trial?

Interventions

  • Low Dose Radiation Therapy

Trial Overview

The study compares one course versus two courses of low-dose radiation therapy (LDRT) to see which works better for improving knee pain, movement, and quality of life over about 3 months.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Two courses of LDRTExperimental Treatment1 Intervention
Group II: One course of LDRTExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials
1,249
Recruited
3,255,000+

Radiation Oncology Institute

Collaborator

Trials
3
Recruited
30+