Search > Obsessive-Compulsive Disorder
40 Participants NeededMy employer runs this trial

Low Intensity Focused Ultrasound for OCD

GR
Overseen ByGiovanna Rocchio
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Pennsylvania
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The study tests ATTN201, an investigational non-invasive headband that delivers low-intensity focused ultrasound (LIFU) to the subthalamic nucleus (STN) as a treatment for obsessive-compulsive disorder (OCD). It's a randomized, double-blind, 1:1 (active: sham) study with 40 total participants spanning 12-16 weeks and 14 in-person and remote visits.

Are You a Good Fit for This Trial?

This trial is for adults diagnosed with obsessive-compulsive disorder (OCD) who are looking for new treatment options. Participants must be able to attend several in-person and remote visits over about 3-4 months.

Inclusion Criteria

I am able and willing to have a cranial MRI scan.
Have a Y-BOCS of > 16
Sign the informed consent form, in accordance with local requirements, after the scope and nature of the investigation have been explained to the subject, and before screening assessments
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Exclusion Criteria

Has a history of traumatic brain injury with loss of consciousness, seizures, or other neurological disorders
I have had deep brain stimulation or brain surgery to destroy tissue.
Has any medical or psychiatric symptoms or conditions that could interfere with study activities or confound interpretation of study results
See 12 more

What Are the Treatments Tested in This Trial?

Interventions

  • ATTN201

Trial Overview

The study is testing a non-invasive headband device called ATTN201 that uses low-intensity focused ultrasound on the brain, compared to a sham (inactive) device. Participants are randomly assigned to either group without knowing which one they get.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Active StimulationExperimental Treatment1 Intervention
Group II: Sham StimulationPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

Attune Neurosciences Inc

Industry Sponsor

Trials
1
Recruited
30+

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