Gut-brain Axis Activating Carbohydrates for Obesity

(GUT BOOST Trial)

This trial examines how special carbohydrates might help control appetite by affecting the brain's hunger signals in children with obesity. Researchers aim to determine if a specific carbohydrate powder, mixed with water and taken twice daily, can increase feelings of fullness. This carbohydrate targets the gut-brain axis, specifically activating GLP-1, a hormone involved in hunger regulation. The trial compares this with a placebo, a harmless substance resembling the treatment. Children aged 12 to 18 with obesity, who are on stable medication doses, may qualify for this study. As a Phase 2 trial, the research focuses on measuring the treatment's effectiveness in an initial, smaller group of participants.

Research has shown that the carbohydrates used in this trial, which activate the gut-brain connection, are generally safe. These carbohydrates come from a mix of raw corn starch and raw potato starch. Past studies have tested this combination for its ability to increase GLP-1, a hormone that helps control appetite. The results showed that this mix is well-tolerated by the body, with no serious side effects reported.

Researchers are excited about these treatments for obesity because they target the gut-brain axis, specifically activating GLP-1, a hormone that plays a crucial role in regulating appetite and metabolism. Unlike current options like medications that suppress appetite or block fat absorption, this treatment uses natural food carbohydrates, like raw corn starch and raw potato starch, to stimulate the body's own pathways for weight regulation. This approach could offer a more natural and potentially safer alternative to traditional pharmacological interventions.

This trial will compare the effects of a gut-brain axis (GLP-1)-activating food carbohydrate supplement, made of raw corn starch and raw potato starch, with a starch-based fast-digesting placebo control using commercial maltodextrin. Research has shown that resistant starches, like those in raw corn and potato starch, can aid weight loss and improve insulin use in the body. One study found that participants who consumed resistant starches lost an average of 2.8 kilograms over eight weeks. These starches increase a hormone called GLP-1, which controls appetite and enhances feelings of fullness. GLP-1 also improves insulin management, benefiting weight and blood sugar control. Additionally, resistant starches have been linked to reduced belly fat and better gut health. Overall, these carbohydrates appear promising for aiding weight loss and enhancing metabolism.¹²⁵⁶⁷