ALN-CIDEB for Non-Alcoholic Fatty Liver Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will test a Regeneron study drug called ALN-CIDEB to find out whether it may help treat a liver disease called MASH.
In this study, researchers are looking at the effect of ALN-CIDEB on reducing liver fat, liver injury, and liver scarring. The study will compare ALN-CIDEB with placebo to understand how well ALN-CIDEB works to lower the amount of fat in the liver.
The study is looking at:
* What side effects ALN-CIDEB might cause
* How well ALN-CIDEB works to change liver fat, liver injury, and liver scarring
* How the body and the liver change after having ALN-CIDEB, which can help researchers understand why ALN-CIDEB works better for some people than others
Who Is on the Research Team?
Clinical Trial Management
Principal Investigator
Regeneron Pharmaceuticals
Are You a Good Fit for This Trial?
This trial is for adults with a type of fatty liver disease called MASH, who have moderate to advanced liver scarring (fibrosis stage F2 or F3) and signs of active liver injury. Participants must show certain test results confirming their diagnosis.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- ALN-CIDEB
Trial Overview
The study compares the new drug ALN-CIDEB to a placebo in people with MASH. Researchers want to see if ALN-CIDEB can reduce fat, injury, and scarring in the liver. Participants are randomly assigned to receive either ALN-CIDEB or placebo.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Regeneron Pharmaceuticals
Lead Sponsor
Leonard Schleifer
Regeneron Pharmaceuticals
Chief Executive Officer since 1988
MD and PhD in Medicine
George Yancopoulos
Regeneron Pharmaceuticals
Chief Medical Officer since 1997
MD from Harvard Medical School
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