Cocoa Supplementation + Exercise for Mobility Disability

(COMET Trial)

This trial explores whether a cocoa supplement, combined with regular exercise, can enhance physical performance and muscle strength more effectively than exercise alone. Participants will take a special cocoa compound, (-)-Epicatechin, while engaging in both aerobic (walking) and resistance exercises. Individuals who have noticed a slower walking pace and are open to trying either the cocoa supplement or a placebo may be suitable candidates. As a Phase 1 and Phase 2 trial, this research aims to understand how the treatment works in people and measure its effectiveness in an initial, smaller group, offering participants a chance to contribute to groundbreaking health advancements.

The trial requires participants to stop taking blood thinners like baby aspirin. Other medications are not specifically mentioned, so it's best to discuss with the trial team.

Research has shown that cocoa supplements, particularly those rich in cocoa flavanols, have been studied for their safety and health benefits. One study with older adults found that daily consumption of natural cocoa for 12 weeks improved muscle mass without significant side effects. Another study discovered that cocoa flavanols could enhance exercise ability and heart health, again without major negative effects.

Most treatments for mobility disability focus on physical therapy or medication to manage symptoms. However, this trial is exploring a unique combination of cocoa flavanols, specifically (-)-epicatechin, with exercise. Researchers are excited about the potential of cocoa flavanols because they may enhance blood flow and muscle function, which could improve mobility more effectively than traditional methods. This approach also emphasizes a natural supplement, which might offer a safer alternative with fewer side effects compared to conventional drugs.

Research has shown that cocoa supplements might enhance exercise performance and mobility. In this trial, one group will receive cocoa supplements with exercise, while another group will receive a placebo with exercise. One study found that participants who took cocoa walked 42.6 meters farther in six minutes, indicating improved walking ability. Another study found that cocoa flavanols increased exercise capacity in healthy older adults. Additionally, cocoa's flavanols benefit heart health and might improve muscle mass and movement. These findings suggest that cocoa supplements could enhance physical performance, especially when combined with regular exercise.¹²⁴⁵⁶