Sulforaphane for Skin Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether sulforaphane, a broccoli sprout extract, can reduce melanoma risk by affecting atypical moles. Participants will take either sulforaphane or a placebo for 12 months to determine if their moles change meaningfully. It suits individuals with at least three unusual moles and a history of early-stage melanoma. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot be on any systemic treatment for melanoma or use other sulforaphane supplements during the study.
Is there any evidence suggesting that sulforaphane is likely to be safe for humans?
Research has shown that sulforaphane, a compound in broccoli sprouts, is generally safe for use. It has been safely used in humans for up to six months. Studies indicate that daily intake of sulforaphane is well-tolerated, and it is often consumed in natural forms, like vegetables, without major side effects.
Sulforaphane has been studied in other trials for its effects on various cancers and conditions. It has shown potential in protecting the skin from sun damage and reducing tumor growth. While these studies suggest that sulforaphane is safe, this trial will provide more information about its safety over a longer period of 12 months.12345Why do researchers think this study treatment might be promising for skin cancer?
Researchers are excited about sulforaphane for skin cancer because it offers a new, natural approach compared to traditional treatments like surgery, topical therapies, or chemotherapy. Sulforaphane is derived from cruciferous vegetables like broccoli, and it works by enhancing the body’s ability to detoxify carcinogens. This unique mechanism may help in preventing cancer cell growth, making it a promising addition to current skin cancer treatment options. Unlike some existing treatments that can have harsh side effects, sulforaphane is generally well-tolerated, which could improve patient experience.
What evidence suggests that sulforaphane might be an effective treatment for skin cancer?
Research has shown that sulforaphane, a compound in broccoli sprouts, can protect skin from UV damage and may slow tumor growth. Studies have found that this extract disrupts the growth and spread of cancer cells. Some evidence suggests that sulforaphane enhances the effectiveness of existing cancer treatments by targeting several cancer-related pathways. These effects make sulforaphane a promising option for reducing melanoma risk, particularly by affecting unusual moles. Although more research is needed, these early findings offer hope for its role in preventing skin cancer. Participants in this trial will receive either sulforaphane in the form of Avmacol® Extra Strength or a placebo to evaluate its effectiveness over 12 months.36789
Who Is on the Research Team?
John Kirkwood, MD
Principal Investigator
UPMC Hillman Cancer Center
Are You a Good Fit for This Trial?
This trial is for individuals who have had melanoma in the past and are at risk of it returning. Participants will take sulforaphane or a placebo for a year, with clinic visits every three months. The study excludes details on specific inclusion and exclusion criteria.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take sulforaphane or a placebo for 12 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Sulforaphane
Find a Clinic Near You
Who Is Running the Clinical Trial?
Eastern Cooperative Oncology Group
Lead Sponsor
National Institutes of Health (NIH)
Collaborator