Hotspot vs Traditional Radiotherapy for Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This clinical trial compares stereotactic ablative radiotherapy (SBRT) with hot spots to standard of care SBRT for the treatment of patients with early-stage non-small cell lung cancer. SBRT with hot spots intentionally makes sure the tumor gets a higher radiation dose during treatment. This potentially may result in better control of the tumor, but also more side effects. SBRT with or without hot spots may be more effective in treating patients with early-stage non-small cell lung cancer, compared to standard of care SBRT.
Who Is on the Research Team?
Mark Farrugia
Principal Investigator
Roswell Park Cancer Institute
Are You a Good Fit for This Trial?
This trial is for adults (18+) with early-stage non-small cell lung cancer who are healthy enough for focused radiation therapy. Participants must not have certain immune or lung conditions, recent overlapping chest radiation, or be pregnant/nursing. They need to use birth control and agree to study procedures.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive either standard of care SBRT or hot spot SBRT for 1-5 fractions over 1-11 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Stereotactic Body Radiation Therapy (SBRT) with Hot Spots
Trial Overview
The study compares two types of focused radiation: standard SBRT versus SBRT that targets the tumor with extra-high doses ('hot spots'). The goal is to see if the higher dose improves tumor control in early-stage non-small cell lung cancer.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Patients receive SOC SBRT for 1-5 fractions over 1-11 days, in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan with or without PET scan and blood sample collection throughout the study. Patients may undergo lymph node sampling throughout the study.
Patients receive hot spot SBRT for 1-5 fractions over 1-11 days, in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan with or without PET scan and blood sample collection throughout the study. Patients may undergo lymph node sampling throughout the study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Roswell Park Cancer Institute
Lead Sponsor
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.