Disulfiram + Copper + Radiotherapy for Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is being done to test whether adding two drugs-disulfiram and copper gluconate-to radiation therapy can help overcome this resistance and improve treatment outcomes. When disulfiram is combined with copper, it forms a substance that may increase stress within cancer cells and lead to a specific type of cancer cell death knowns as "cuproptosis".
Who Is on the Research Team?
Steven Lin, MD, PHD
Principal Investigator
UT MD Anderson
Are You a Good Fit for This Trial?
This trial is for people with lung cancer who are eligible to receive radiation therapy. Participants should be able to safely take disulfiram and copper gluconate, and not have any medical conditions or allergies that would make these treatments unsafe.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Copper Gluconate
- Disulfiram
- Radiation Therapy
Trial Overview
The study tests if adding disulfiram (250 mg) and copper gluconate (2 mg) to standard radiation therapy helps treat lung cancer better by causing more stress in cancer cells, possibly leading to their death. All participants will get the combination treatment.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
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