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PET/CT Imaging for Glioma

CJ
Overseen ByCsaba Juhasz, M.D.,Ph.D.
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Barbara Ann Karmanos Cancer Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to evaluate Positron emission tomography/computed tomography (PET/CT) imaging with the radiotracer 1-(2-\[18F\]fluoroethyl)-l-tryptophan (\[18F\]FETrp) in patients diagnosed with a glioma. This study has 3 aims:

* to assess if the \[18F\]FETrp PET/CT can outperform Magnetic Resonance Imaging (MRI) by providing a better treatment target volume in newly diagnosed Stage 4 glioma patients

* better differentiate tumor progression from radiation induced MRI changes in post treatment stage 4 gliomas

* by giving a drug that can inhibit a pathway to allow objective assessment of treatment effects in low grade gliomas

Who Is on the Research Team?

CJ

Csaba Juhasz, M.D.,Ph.D.

Principal Investigator

Wayne State University

Are You a Good Fit for This Trial?

This trial is for people diagnosed with glioma (including low grade and glioblastoma) or other solid brain tumors. Participants may be newly diagnosed or have already received treatment.

Inclusion Criteria

I have a brain tumor diagnosed as low-grade glioma (WHO grade 2, IDH mutant).
Arm 3: Detected mass on the most recent clinical MRI is at least 7 mm in bidirectional diameter
Arm 3: Most recent MRI used for comparison with the PET/CT is performed within 4 weeks
See 12 more

Exclusion Criteria

I have had colitis while taking antibiotics.
I have an active connective tissue disorder like lupus or scleroderma.
Arm 3: History of allergic reaction to minocycline or any tetracyclines
See 4 more

What Are the Treatments Tested in This Trial?

Interventions

  • [18F]FETrp PET/CT
  • Minocycline

Trial Overview

The study is testing a special PET/CT scan using the tracer [18F]FETrp to see if it gives better information than MRI in brain tumor patients. Some participants will also take minocycline, an antibiotic, to help assess its effects on imaging results.

How Is the Trial Designed?

3

Treatment groups

Experimental Treatment

Group I: [18F]FETrp PET/CT pre and post Minocycline 200mg/dayExperimental Treatment2 Interventions
Group II: [18F]FETrp PET/CT in previously treated gliomas with post radiation progressionExperimental Treatment1 Intervention
Group III: [18F]FETrp PET/CT in newly diagnosed grade 4 glioma prior to radiationExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Barbara Ann Karmanos Cancer Institute

Lead Sponsor

Trials
166
Recruited
9,300+

Wayne State University

Collaborator

Trials
318
Recruited
111,000+

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