Non-Invasive Vagus Nerve Stimulation for PTSD

This trial examines whether a non-invasive device that stimulates the vagus nerve can reduce PTSD symptoms, improve pain response, and enhance life quality for veterans. Participants will use a device on the neck daily, with effects compared to a similar device that does not actively stimulate the nerve. Veterans who have been deployed, experienced trauma, and face PTSD symptoms might be suitable candidates for this study. As a Phase 1/Phase 2 trial, the research aims to understand how the treatment works and measure its effectiveness in an initial, smaller group, offering participants a chance to contribute to groundbreaking PTSD treatment advancements.

The trial requires that participants continue taking standard medications used to treat PTSD. However, if you take anti-inflammatory medications for chronic conditions or medications for chronic pain, you will be excluded from the trial.

Research has shown that cervical transcutaneous vagus nerve stimulation (tcVNS) is generally safe for people with PTSD. In past studies, patients handled the treatment well. One study found that tcVNS reduced certain stress-related inflammation without causing major side effects. Another study demonstrated that it helped lower stress responses in people with PTSD, suggesting its safety. While these studies show promising safety results, it is important to remember that this treatment is still under investigation. Further research could confirm its safety and effectiveness.¹²³⁴⁵

Most treatments for PTSD involve psychotherapy or medications like SSRIs and SNRIs, which work by altering brain chemistry over time. However, cervical transcutaneous vagus nerve stimulation (tVNS) is different because it uses a non-invasive device to directly stimulate the vagus nerve through the skin on the neck. This method is unique because it could potentially modulate brain activity more directly and rapidly than traditional drugs. Researchers are excited about tVNS because it offers a new way to address PTSD symptoms without the side effects associated with medications, and it may provide faster relief than current therapeutic options.

Research has shown that cervical transcutaneous vagus nerve stimulation (tcVNS), a treatment participants in this trial may receive, might help people with PTSD by reducing stress. One study found that tcVNS lowered heart rates in people with PTSD, suggesting it helps calm stress. Another study indicated that tcVNS might improve attention and memory, potentially enhancing quality of life. Additionally, tcVNS has reduced the body's inflammatory response to stress. These findings suggest that tcVNS could help lessen PTSD symptoms and improve daily life.¹²³⁶⁷