Hyperpolarized 129 Xenon for Respiratory Issues After Bone Marrow Transplant
What You Need to Know Before You Apply
What is the purpose of this trial?
This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and healthy control volunteers. The participants will be male or female between 3-17 years old (children) and adults age 18 and older.
The study objective is to:
* To optimize the acquisition of images reflecting the "dissolved-phase" Xe distribution in the pulmonary tissues and blood (Xe gas-exchange MRI).
* To develop and test Xe MRI acquisition strategies that separately image alveolar airspace distribution (ventilation), as well as Xe dissolved in pulmonary tissues versus red blood cells (RBCs).
* To acquire images of Xe ventilation and dissolved-phase Xe regional distribution in the enrolled participants.
* To understand the same-day variability of Xe MRI techniques.
* To determine the relationship between Xe MRI and clinical measures such as pulmonary-function-test (PFT) parameters or other biological biomarkers.
* To develop and optimize strategies for Xe MRI in young children including those who are unable to follow the inhalation and breath-hold instructions typical of the Xe MRI procedure.
Who Is on the Research Team?
Laura Walkup, PhD
Principal Investigator
Children's Hospital Medical Center, Cincinnati
Are You a Good Fit for This Trial?
This trial is for children (ages 3-17) and adults (18+) who are being evaluated for or have had a bone marrow transplant, have breathing problems or impaired lung function, as well as healthy volunteers. Both males and females can participate.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Hyperpolarized 129 Xenon
Trial Overview
The study tests a special MRI scan using hyperpolarized xenon gas to take detailed pictures of how lungs work in different people. It aims to improve imaging techniques for both patients with lung issues and healthy controls.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Hyperpolarized xenon gas will be administered in doses of up to 1/6TLC (based on either ATS calculations that utilize gender and height to determine the dose or plethysmography data) for participants under 18 years old and 1000 milliliters for adults per our previous research experience followed by a breath hold of up to 16 seconds
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
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