Pre-Radiation Chemotherapy for Brain Cancer
(PRC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well. After radiation, MRI scans can be harder to understand because radiation changes how the brain looks on the scan. If new medicines are given before radiation, the scans are easier to read.
First, the investigators need to find out if giving chemotherapy early works using a drug we already know can treat gliomas. The investigators will start with temozolomide, which is the only chemotherapy approved by the FDA for HGG. If this approach is successful, the investigators can then test new drugs using this screening method.
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 with a newly diagnosed high-grade brain tumor (like glioblastoma) who still have some tumor left after surgery, are well enough to participate, and do not need urgent radiation or chemo. Participants must be able to take oral medication and agree to use birth control if needed.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Temozolomide
Trial Overview
The study tests giving the chemotherapy drug temozolomide before starting radiation in people with high-grade gliomas. The goal is to see if early chemo helps treatment and makes MRI scans easier to interpret before any changes from radiation appear.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cooper Health System
Lead Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborator
University of Virginia
Collaborator
Virginia Commonwealth University
Collaborator
Wake Forest University
Collaborator
Georgetown University
Collaborator
Musella Foundation
Collaborator
Imaging Biometrics, LLC
Industry Sponsor
West Virginia University
Collaborator
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