Aflibercept + Ahmed Tube Surgery for Glaucoma
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine if injections of aflibercept into the eye given at the end of the Ahmed tube surgery as well as at postoperative months one and two would improve eye pressure control compared to standard surgery with no aflibercept.
Who Is on the Research Team?
Adam Rothman, MD
Principal Investigator
University of Miami
Are You a Good Fit for This Trial?
This trial is for people with glaucoma who are scheduled to have Ahmed tube surgery. Participants should not have conditions or factors that would prevent them from safely receiving eye injections or undergoing this type of eye surgery.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Aflibercept Injection
- Ahmed Tube Surgery
Trial Overview
The study compares standard Ahmed tube surgery alone versus the same surgery plus aflibercept injections into the eye, given during and after the operation, to see if it better controls eye pressure.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will undergo standard of care Ahmed tube surgery and will receive one 8 mg injection of intravitreal aflibercept at three timepoints in the study: at the conclusion of surgery, Postoperative Month 1, Postoperative Month 2. Total duration of participation in this arm is 6 months
Participants will undergo standard of care Ahmed tube surgery without any injections of intravitreal aflibercept. Total duration of participation in this arm is 6 months.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Miami
Lead Sponsor
Regeneron Pharmaceuticals
Industry Sponsor
Leonard Schleifer
Regeneron Pharmaceuticals
Chief Executive Officer since 1988
MD and PhD in Medicine
George Yancopoulos
Regeneron Pharmaceuticals
Chief Medical Officer since 1997
MD from Harvard Medical School
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