Wegovy + Mirena for Endometrial Cancer
(WE-FiERCE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The incidence of endometrial cancer is increasing at an alarming rate. This trend parallels the rising rate of obesity, the most significant risk factor for endometrial cancer. Young women with obesity and endometrial cancer or atypical hyperplasia who want to maintain their fertility are treated with progestin therapy, such as progestin intra-uterine device (pIUD), which is associated with a mediocre response rate and high recurrence rate, and does not address the underlying cause, obesity. Therefore, the investigators want to assess whether the addition of a weight-loss drug to pIUD will improve their oncologic, reproductive and metabolic outcomes.
Who Is on the Research Team?
Rachel Soyoun Kim, MD
Principal Investigator
University Health Network, Toronto
Sarah E Ferguson, MD
Principal Investigator
University Health Network, Toronto
Are You a Good Fit for This Trial?
This trial is for women with early-stage, low-grade endometrial cancer or atypical hyperplasia who are overweight (BMI of 27 or higher), want to preserve fertility, have no spread of disease outside the uterus, and are able to give informed consent.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Mirena
- Wegovy
Trial Overview
The study compares standard hormone therapy using a progestin-releasing IUD (Mirena) alone versus Mirena combined with Wegovy, a weight-loss drug. The goal is to see if adding Wegovy improves cancer treatment and overall health outcomes.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
All patients will receive a progestin intrauterine device and semaglutide subcutaneous injections
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Health Network, Toronto
Lead Sponsor
GynOncTrials
Lead Sponsor
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