Written Exposure Therapy + Methylphenidate for PTSD
(WET+MPH Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Many Veterans with post-traumatic stress disorder (PTSD) do not fully benefit from the best current treatments, some of which focus on helping the brain regulate trauma memories. While therapies like Prolonged Exposure and Written Exposure Therapy work for many, about half of Veterans still struggle with symptoms even after treatment. Research suggests that methylphenidate (commonly known as Ritalin), a safe and widely used medication, may improve PTSD symptoms and related mechanisms. This project will test whether adding methylphenidate to Written Exposure Therapy will result in a greater reduction in PTSD symptoms compared to Written Exposure Therapy alone. The investigators will also study body and behavior markers to better understand how and why some Veterans respond to treatment. If successful, this approach could give providers a new, practical tool to improve recovery from PTSD. Ultimately, this work could lead to more personalized, effective care for Veterans, helping them return to fuller and healthier lives.
Who Is on the Research Team?
Andrea Townsend, PhD
Principal Investigator
VA San Diego Healthcare System, San Diego, CA
Victoria B Risbrough
Principal Investigator
VA San Diego Healthcare System, San Diego, CA
Are You a Good Fit for This Trial?
This trial is for Veterans diagnosed with PTSD who are seeking treatment. Participants should be able to take part in therapy sessions and medication use, as determined by the study team. People with certain medical or psychiatric conditions that could interfere with participation may not be eligible.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Methylphenidate
- Written Exposure Therapy
Trial Overview
The study tests whether adding methylphenidate (a medication often used for ADHD) to Written Exposure Therapy helps reduce PTSD symptoms more than therapy alone. Some participants will get methylphenidate, others a placebo, along with the same therapy.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Written Exposure Therapy plus methylphenidate (MPH 40mg)
Written Exposure Therapy plus placebo (PBO)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
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