Olomorasib for Colorectal Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The main purpose of this study is to evaluate how well olomorasib is tolerated and what side effects may occur when combined with other interventions in participants with Kirsten rat sarcoma viral oncogene homolog (KRAS) G12C-mutant, locally advanced colorectal cancer (CRC) that cannot be removed with surgery or has spread to other parts of the body. Blood tests will be performed to investigate how the body processes the study drug.
Who Is on the Research Team?
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Principal Investigator
Eli Lilly and Company
Are You a Good Fit for This Trial?
This trial is for adults with advanced colorectal cancer that has a KRAS G12C mutation and cannot be removed by surgery or cured with radiation. Participants must not have had treatment for cancer that has spread, need to be in good physical condition, able to swallow capsules, and have working major organs.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- 5-fluorouracil
- Cetuximab
- Leucovorin/levofolinate calcium
- Olomorasib
- Oxaliplatin
Trial Overview
The study tests the safety and effects of olomorasib alone or combined with other drugs (cetuximab, oxaliplatin, leucovorin/levofolinate calcium, 5-fluorouracil) in people with advanced KRAS G12C-mutant colorectal cancer. Blood samples will help understand how the drug works in the body.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Olomorasib administered orally; Cetuximab, fluorouracil, leucovorin \& oxaliplatin administered intravenously (IV)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Eli Lilly and Company
Lead Sponsor
Dr. Daniel Skovronsky
Eli Lilly and Company
Chief Medical Officer since 2018
MD from Harvard Medical School
David A. Ricks
Eli Lilly and Company
Chief Executive Officer since 2017
BSc from Purdue University, MBA from Indiana University
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