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Fisetin for Aging

SH
Overseen BySarah Haydu
Age: 65+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Colorado, Boulder
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

Aging is associated with the development of vascular dysfunction, which increases the risk for cardiovascular disease. This clinical trial will assess if supplementation with the natural compound fisetin can improve vascular endothelial function in older adults. The clinical trial will also assess if any effects of fisetin on endothelial function are associated with reduced cellular senescence. The study will also evaluate safety, tolerability and adherence with fisetin treatment.

Who Is on the Research Team?

MJ

Matthew J Rossman, PhD

Principal Investigator

University of Colorado, Boulder

Are You a Good Fit for This Trial?

This trial is for older adults who may have age-related blood vessel problems but are otherwise healthy. People with serious health conditions or on certain medications might not be able to join.

Inclusion Criteria

I am able to understand and follow all study instructions.
Absence of established, serious, unstable, chronic clinical disease (e.g., unstable cardiovascular disease) that would make it unsafe for the individual to participate in the trial as determined by trial physician of record
Body mass index (BMI) less than 40 kg/m2
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Exclusion Criteria

Inability to refrain from alcohol for 24 hours prior to outcome assessment, alcohol dependence or abuse
I am not taking supplements or drugs that may have senolytic effects.
Resting blood pressure greater than 160 mmHg systolic or greater than 100 mmHg diastolic
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What Are the Treatments Tested in This Trial?

Interventions

  • Fisetin

Trial Overview

The study tests whether taking fisetin, a natural supplement, can improve blood vessel function in older adults compared to a placebo (inactive pill). Participants are randomly assigned to either the fisetin or placebo group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: FisetinExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Boulder

Lead Sponsor

Trials
128
Recruited
29,600+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

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