Clazakizumab for Cardiovascular Disease

(CLARITY-CRP Trial)

Not yet recruiting at 46 trial locations
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Eli Lilly and Company
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event.

Participation in the study will last about 9 months.

Who Is on the Research Team?

C1

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Principal Investigator

Eli Lilly and Company

Are You a Good Fit for This Trial?

Inclusion Criteria

At least one of the following chronic conditions: obesity (body mass index (BMI) ≥30 kg/m2)
I have chronic high blood pressure.
hsCRP ≥2 mg/L and ≤15 mg/L at screening
See 3 more

Exclusion Criteria

I have used steroid medications in the past 14 days.
I am scheduled for heart surgery or another major surgery soon.
My blood pressure is not controlled and is very high.
See 18 more

What Are the Treatments Tested in This Trial?

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Placebo Group

Group I: Clazakizumab Dose 3Experimental Treatment1 Intervention
Group II: Clazakizumab Dose 2Experimental Treatment1 Intervention
Group III: Clazakizumab Dose 1Experimental Treatment1 Intervention
Group IV: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Eli Lilly and Company

Lead Sponsor

Trials
2,708
Recruited
3,720,000+
Dr. Daniel Skovronsky profile image

Dr. Daniel Skovronsky

Eli Lilly and Company

Chief Medical Officer since 2018

MD from Harvard Medical School

David A. Ricks profile image

David A. Ricks

Eli Lilly and Company

Chief Executive Officer since 2017

BSc from Purdue University, MBA from Indiana University