Cannabidiol for Bipolar Disorder

This trial tests a high-CBD solution (Cannabidiol) to determine its effects on people with bipolar disorder who also experience anxiety. Researchers aim to discover if CBD can reduce anxiety and improve mood in these individuals. Participants will take the CBD solution twice daily for four weeks. The trial seeks individuals diagnosed with bipolar disorder (type I or II), who experience moderate anxiety, and are on a stable medication routine. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important findings.

The trial requires that participants are on a stable medication regimen, but it does not specify if you need to stop any current medications. However, if you are using valproate or divalproex, you cannot participate.

Research has shown that cannabidiol (CBD) is generally safe for people. Studies have found that most individuals tolerate CBD well. Common side effects, such as reduced appetite, are usually mild. In these studies, CBD did not cause anxiety or mood issues, making it a promising option for treating conditions like bipolar disorder. Additionally, CBD has already received approval for some other medical conditions, further supporting its safety. Overall, current evidence suggests that CBD is a safe treatment option for many people.¹²³⁴⁵

Unlike standard treatments for bipolar disorder, which often include mood stabilizers like lithium or antipsychotics, the treatment under study uses cannabidiol (CBD), a compound derived from hemp. Researchers are excited about CBD because it has a new mechanism of action, potentially offering mood stabilization without the side effects commonly associated with traditional medications. Additionally, CBD is known for its anti-inflammatory and neuroprotective properties, which could provide a more holistic approach to managing bipolar disorder symptoms. This treatment could offer a natural alternative with fewer side effects, making it an appealing option for patients seeking different ways to manage their condition.

Research has shown that cannabidiol (CBD) might help stabilize mood, potentially benefiting people with bipolar disorder. Some small studies found that CBD can improve mood-related issues such as depression and anxiety. It generally has a good safety record, meaning it usually doesn't cause negative effects like anxiety or psychotic symptoms. Although more research is needed, early results suggest CBD could help manage mood disorders. Participants in this trial will receive a custom-formulated, hemp-derived, high-CBD solution to further evaluate its effects.²⁵⁶⁷⁸