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Preoperative Gas for Retinal Detachment

Not yet recruiting at 1 trial location
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Overseen ByZainab Rustam, MD
Age: 18+
Sex: Any
Trial Phase: Phase 2 & 3
Sponsor: Wills Eye
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD). While current surgical therapies successfully reattach the retina, visual recovery can vary. This study will investigate if injecting a small amount of gas (0.3 cc of 100% C3F8) into the eye prior to standard surgery can decrease the duration of macular detachment, reduce retinal displacement, and ultimately result in better final visual acuity compared to the standard of care alone.

Who Is on the Research Team?

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Ajay Kuriyan, MD

Principal Investigator

Wills Eye Hospital

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Sidra Zafar, MD

Principal Investigator

The Johns Hopkins Wilmer Eye Institute

Are You a Good Fit for This Trial?

This trial is for people with a type of retinal detachment called macula-off rhegmatogenous retinal detachment who are scheduled for surgery to repair it. Participants should not have other eye conditions or factors that would interfere with the study.

Inclusion Criteria

Willing and able to comply with clinic visits and study-related procedures
I have a retinal detachment that involves the macula.
I agree to have eye surgery called pars plana vitrectomy, with or without scleral buckling.

Exclusion Criteria

I have PVR grade C or worse at the time of my eye surgery.
I am not able to sign a consent form for this study.
I have or had serious eye conditions or diseases affecting the retina or inside of my eye.
See 5 more

What Are the Treatments Tested in This Trial?

Interventions

  • Intravitreal 100% C3F8 Injection
  • Pars plana vitrectomy or pars plana vitrectomy with scleral buckle

Trial Overview

The study compares standard retina reattachment surgery (pars plana vitrectomy, sometimes with scleral buckle) alone versus the same surgery after injecting a small amount of gas (C3F8) into the eye before surgery, to see if this improves vision recovery.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Preoperative GasExperimental Treatment2 Interventions
Group II: Standard of CareActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Wills Eye

Lead Sponsor

Trials
81
Recruited
15,400+

Johns Hopkins University

Collaborator

Trials
2,366
Recruited
15,160,000+

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