Elranatamab for Plasmablastic Lymphoma
(HEME-25 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a single-arm feasibility trial in which patients with histologically confirmed plasmablastic lymphoma (PBL) with or without HIV, who have achieved a Complete Response or Partial Response after definitive frontline chemotherapy, will receive Elranatamab (Elra) consolidation.
Who Is on the Research Team?
Paul Rubinstein, MD
Principal Investigator
university of Illinois Chicago Campus
Are You a Good Fit for This Trial?
This trial is for adults (18+) with confirmed plasmablastic lymphoma, with or without HIV, who have responded at least partially to initial chemotherapy. Participants must be in good physical condition and able to follow study procedures.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Elranatamab
Trial Overview
The study tests Elranatamab as a follow-up treatment (consolidation) for people whose plasmablastic lymphoma improved after first-line chemo. All participants receive the same treatment; there is no comparison group.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients will receive Elra subcutaneously for up to six 28-day cycles, beginning with a step-up dosing schedule (12 mg on day 1, 32 mg on day 4, followed by 76 mg weekly on days 8, 15, and 22 of Cycle 1). Patients will transition to 76 mg every 2 weeks (days 1 and 15) during Cycles 2 and 3, followed by an interim PET/CT assessment at the end of Cycle 3. During Cycles 4 through 6, all patients will receive 76 mg every 4 weeks (on day 1 of each cycle).
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Illinois at Chicago
Lead Sponsor
Pfizer
Industry Sponsor
Albert Bourla
Pfizer
Chief Executive Officer since 2019
PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki
Patrizia Cavazzoni
Pfizer
Chief Medical Officer
MD from McGill University
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