Semaglutide for Type 1 Diabetes
(SEMA-T1D-BODY Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this 24 week double-blinded, randomized, parallel controlled clinical trial is to learn how semaglutide affects body composition in adults with type 1 diabetes and overweight/obesity.
The main question to answer is:
What effect does Semaglutide have on body composition in adults with type 1 diabetes and overweight/obesity compared to a placebo?
Around 40 participants will:
* Be randomly assigned to receive semaglutide or a placebo.
* Self-administer the treatment drug once per week for 24 weeks.
* Complete a series of tests, measurements and questionnaires throughout the study duration.
* Attend a remote follow-up visit 4 weeks after the treatment is complete.
Who Is on the Research Team?
Melissa-Rosina Pasqua, MD, PhD
Principal Investigator
Research Institute of the McGill University Health Centre Royal Victoria Hospital
Are You a Good Fit for This Trial?
This trial is for adults with type 1 diabetes who are also overweight or obese. Participants must be able to self-administer medication and take part in study visits and tests.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Semaglutide
Trial Overview
The study compares semaglutide (a weekly injection) to a placebo over 24 weeks, aiming to see how semaglutide affects body composition in people with type 1 diabetes and excess weight. Participants are randomly assigned to either group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants will receive semaglutide via subcutaneous injection once a week for 24 weeks. Dosing will begin at 0.25 mg and will be increased every 4 weeks, to a maximum of 2.4 mg, if tolerated.
Participants will receive a 0.9% normal saline placebo via subcutaneous injection once a week for 24 weeks. Dosing will begin at 0.25 mg and increase every 4 weeks until a maximum of 2.4 mg.
Find a Clinic Near You
Who Is Running the Clinical Trial?
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
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